Overview

CytoFast cabinets embody the latest European control and filtration technology, together with class-leading ergonomics and functionality. Cabinets are free-standing are available in widths of 900 mm, 1200 mm and 1800 mm; all with exhaust discharge at the top. Cabinets comply fully with Australian standard AS 2567, DIN 12980 and the EU standard EN 12469. An electric sash front window with smooth, silent operation can be raised to a maximum opening of 420 mm for cleaning or movement of materials; or completely closed, obviating the need for a work zone closure panel. Glass side panels are fitted in the work zone. Cabinets are available in isolator configuration with glove ports and H14 HEPA-filtered transfer hatches. This version conforms to Class III in ISO 14644-7.

Applications

Pharmaceuticals Cytotoxic drug safety cabinets (CDSCs) are defined in Australian standards AS 2567 and AS 2639 as the primary barrier against exposure to aerosols produced in the preparation, manipulation and dispensing of cytotoxic drugs.Many of these drugs were shown to be mutagens and some to be carcinogens in cell DNA and chromosomal studies. Additionally, a causal relationship has been shown between occupational exposure of unprotected pregnant women to these drugs and increased incidence of teratogenesis. Effects of exposure to these drugs are insidious and may not manifest themselves for some years. Class II biological safety cabinets are unsuitable for use with cytotoxic drugs because aerosols recirculated within the cabinet contaminate fans and internal plenums, thereby exposing service personnel to contaminated surfaces.

Animal studies

An increasing number of animal-based studies involve the use of cytotoxic drugs, and some of this work has been carried out in Class II cabinets. Hazards posed to service personnel from this inappropriate use are now more widely understood, with the result that CDSCs are now specified more frequently for these applications. These cabinets are also suitable for use with agents likely to cause genetic alterations or synergetic activities with other materials.

Airflows and Protection

Personnel and environment protection is provided by an air barrier at the work opening and H14 HEPA filtration of exhaust air. Inflow of ambient air into a full-width grille in the work opening creates the air barrier. A quantity of air equal to the barrier inflow is exhausted to the room through the exhaust filter. Vertical laminar airflow recirculated within the work zone through a second H14 HEPA filter maintains a sterile environment for product protection. Location of the exhaust filter system directly under the work tray prevents recirculation of aerosols of drug products to fans and internal plenums, thus protecting service personnel.

ECS® control and energy management

The new ECS® (Eco Control System) microprocessor employs the latest technology for integrated management of airflows and filtration. Self-regulation of airflows compensates for gradual loading of filters, while restoring power balance. Combining AC fans and certified low pressure-drop filters, the ECS® system optimises power consumption, thereby reducing CO₂emissions into the environment.